What are the main types of enzyme inhibition?

The main types of enzyme inhibition are: Competitive inhibition - inhibitor competes with substrate for the active site, increasing apparent Km but not affecting Vmax; Uncompetitive inhibition - inhibitor binds only to enzyme-substrate complex, decreasing both Km and Vmax; Non-competitive inhibition - inhibitor binds to a site other than active site (allosteric site), reducing Vmax without affecting Km; Mixed inhibition - inhibitor can bind enzyme with or without substrate bound, affecting both Km and Vmax. These patterns are distinguished by Lineweaver-Burk plots and have important implications for drug design.