What is a cell bank system and why is it important?

A cell bank system is a collection of cryopreserved cells derived from a single clone, providing a consistent and characterized source of production organisms. The master cell bank (MCB) is prepared from the original clone after verification. Working cell banks (WCB) are derived from the MCB for routine production. This tiered system provides: genetic consistency across production campaigns, traceability to characterized starting material, protection against culture loss, and regulatory compliance. Cell banks are characterized for identity, purity (absence of contaminating organisms, viruses), genetic stability, and productivity. Banks are stored in multiple locations with appropriate security.