What is the difference between a list and a tuple in Python?

Lists are mutable (can be modified after creation), use square brackets [], and are used for collections that may change. Tuples are immutable (cannot be modified), use parentheses (), and are used for fixed collections. Tuples are faster than lists due to immutability and can be used as dictionary keys. Lists have methods like append() and remove(); tuples don't. Use tuples for coordinates, database records, or when you want to ensure data integrity. Use lists when you need to modify the collection.