How do you optimize a part design when multiple manufacturing processes are involved (casting + machining)?

Multi-process optimization involves: analyzing functional requirements to determine which features need tight tolerances, designing as-cast geometry with appropriate draft, shrinkage allowance, and parting lines, adding machining stock only on critical surfaces (typically 2-4mm), considering fixture locations and clamping during machining, ensuring adequate datum surfaces for machining setup, minimizing material removal while achieving required tolerances, designing cast features to reduce machining operations. Cost analysis should compare near-net-shape casting with more machining versus simpler casting with extensive machining.