How do you optimize the operation of a fluidized bed dryer for pharmaceutical granules?

Optimization parameters: inlet air temperature (balance drying rate vs. product stability, typically 40-80C for pharma), fluidization velocity (1.5-2x minimum fluidization for good mixing without entrainment), humidity of inlet air (low for fast drying, controlled for coating), batch time optimization using moisture endpoint detection (NIR, capacitance). Critical quality attributes: residual moisture content, particle size distribution (avoid attrition), bulk density. PAT implementation allows real-time control and consistent endpoint determination.