How do you design and select isolation amplifiers for safety-critical applications requiring high voltage isolation?

Safety-critical isolation design: specify reinforced isolation per IEC 61010/62368 (not just basic isolation), consider creepage and clearance requirements based on working voltage and pollution degree, select isolation technology (capacitive or transformer-based with >5 kV withstand), verify continuous working voltage rating (not just test voltage), address partial discharge inception voltage for reliable long-term operation. Specify: CMR (common-mode rejection at frequencies up to hundreds of kHz), isolation capacitance (affects high-frequency CMRR), and bandwidth limiting to reduce noise coupling. For SIL-rated applications, verify safety manual data and implement per IEC 61508. Test isolation integrity periodically in maintenance procedures.